269890

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3514774..3515394 Replicon chromosome
Accession NZ_CP117033
Organism Salmonella enterica strain PIW95_S14_0299

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP07_RS17415 Protein ID WP_001280991.1
Coordinates 3515176..3515394 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP07_RS17410 Protein ID WP_000344807.1
Coordinates 3514774..3515148 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP07_RS17400 (3509913) 3509913..3511106 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP07_RS17405 (3511129) 3511129..3514278 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQP07_RS17410 (3514774) 3514774..3515148 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP07_RS17415 (3515176) 3515176..3515394 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP07_RS17420 (3515573) 3515573..3516124 + 552 WP_001278792.1 maltose O-acetyltransferase -
PQP07_RS17425 (3516241) 3516241..3516711 + 471 WP_000136181.1 YlaC family protein -
PQP07_RS17430 (3516767) 3516767..3516907 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP07_RS17435 (3516913) 3516913..3517173 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP07_RS17440 (3517398) 3517398..3518948 + 1551 WP_000213139.1 EAL domain-containing protein -
PQP07_RS17450 (3519179) 3519179..3519568 + 390 WP_000961285.1 MGMT family protein -
PQP07_RS17455 (3519601) 3519601..3520170 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T269890 WP_001280991.1 NZ_CP117033:3515176-3515394 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT269890 WP_000344807.1 NZ_CP117033:3514774-3515148 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References