Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapD-relB/-
Location 188734..189391 Replicon chromosome
Accession NZ_CP117024
Organism Helicobacter pylori strain 444A6

Toxin (Protein)


Gene name VapD Uniprot ID I9U8Q7
Locus tag PPK11_RS00910 Protein ID WP_000271055.1
Coordinates 189107..189391 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PPK11_RS00905 Protein ID WP_273898209.1
Coordinates 188734..189126 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPK11_RS00885 (183925) 183925..185038 + 1114 Protein_159 hydrogenase formation protein HypD -
PPK11_RS00900 (186018) 186018..188132 + 2115 WP_273898208.1 outer membrane beta-barrel protein -
PPK11_RS00905 (188734) 188734..189126 + 393 WP_273898209.1 hypothetical protein Antitoxin
PPK11_RS00910 (189107) 189107..189391 + 285 WP_000271055.1 endoribonuclease VapD Toxin
PPK11_RS00915 (189590) 189590..190114 - 525 WP_001135632.1 acyl-CoA thioesterase -
PPK11_RS00920 (190254) 190254..191108 + 855 WP_273898212.1 SDR family oxidoreductase -
PPK11_RS00925 (191101) 191101..192081 + 981 WP_000921461.1 iron ABC transporter permease -
PPK11_RS00930 (192081) 192081..192848 + 768 WP_108356873.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11215.81 Da        Isoelectric Point: 5.2187

>T269874 WP_000271055.1 NZ_CP117024:189107-189391 [Helicobacter pylori]
MYALAFDLKIEILKKEYKEPYNKAYDDLRQELELLGFENTQGSVYVNYSKENTLVQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Download         Length: 285 bp

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15273.42 Da        Isoelectric Point: 8.7031

>AT269874 WP_273898209.1 NZ_CP117024:188734-189126 [Helicobacter pylori]
MPNTTAKKDYTKYSEKQLFNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDAVNGVNLTQIDSLDDLTNELKRENNKGFENVCFSV

Download         Length: 393 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I9U8Q7

Antitoxin

Source ID Structure

References