Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 4844046..4844751 Replicon chromosome
Accession NZ_CP117020
Organism Escherichia coli strain MLI106K3

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag NL424_RS23425 Protein ID WP_000539521.1
Coordinates 4844365..4844751 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NL424_RS23420 Protein ID WP_001280945.1
Coordinates 4844046..4844375 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL424_RS23405 (4839203) 4839203..4840114 + 912 WP_001236042.1 glutathione ABC transporter permease GsiD -
NL424_RS23410 (4840292) 4840292..4842640 + 2349 WP_001328220.1 EAL domain-containing protein -
NL424_RS23415 (4842648) 4842648..4843976 + 1329 WP_049068068.1 GGDEF domain-containing protein -
NL424_RS23420 (4844046) 4844046..4844375 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
NL424_RS23425 (4844365) 4844365..4844751 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL424_RS23430 (4844977) 4844977..4846302 - 1326 WP_000049378.1 30S ribosomal protein S12 methylthiotransferase RimO -
NL424_RS23435 (4846515) 4846515..4846898 + 384 WP_000497137.1 biofilm formation regulator BssR -
NL424_RS23440 (4847009) 4847009..4848124 + 1116 WP_001595547.1 aldose sugar dehydrogenase YliI -
NL424_RS23445 (4848121) 4848121..4848747 - 627 WP_001595548.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T269872 WP_000539521.1 NZ_CP117020:c4844751-4844365 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT269872 WP_001280945.1 NZ_CP117020:c4844375-4844046 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References