Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4395912..4396530 Replicon chromosome
Accession NZ_CP117020
Organism Escherichia coli strain MLI106K3

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NL424_RS21360 Protein ID WP_001291435.1
Coordinates 4395912..4396130 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NL424_RS21365 Protein ID WP_000344800.1
Coordinates 4396156..4396530 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL424_RS21325 (4391201) 4391201..4391773 + 573 WP_000779831.1 YbaY family lipoprotein -
NL424_RS21330 (4391804) 4391804..4392115 - 312 WP_000409911.1 MGMT family protein -
NL424_RS21340 (4392494) 4392494..4392847 + 354 WP_001550741.1 DUF1428 family protein -
NL424_RS21345 (4392889) 4392889..4394439 - 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NL424_RS21350 (4394603) 4394603..4395073 - 471 WP_000136192.1 YlaC family protein -
NL424_RS21355 (4395189) 4395189..4395740 - 552 WP_000102564.1 maltose O-acetyltransferase -
NL424_RS21360 (4395912) 4395912..4396130 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NL424_RS21365 (4396156) 4396156..4396530 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NL424_RS21370 (4397076) 4397076..4400225 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
NL424_RS21375 (4400248) 4400248..4401441 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269871 WP_001291435.1 NZ_CP117020:c4396130-4395912 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269871 WP_000344800.1 NZ_CP117020:c4396530-4396156 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References