Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 210117..210901 Replicon chromosome
Accession NZ_CP117020
Organism Escherichia coli strain MLI106K3

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag NL424_RS01405 Protein ID WP_000613626.1
Coordinates 210117..210611 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID L4JCW6
Locus tag NL424_RS01410 Protein ID WP_001110447.1
Coordinates 210608..210901 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL424_RS01385 (205310) 205310..206407 + 1098 WP_001441925.1 flagellar basal body P-ring protein FlgI -
NL424_RS01390 (206407) 206407..207348 + 942 WP_001366226.1 flagellar assembly peptidoglycan hydrolase FlgJ -
NL424_RS01395 (207414) 207414..209057 + 1644 WP_000096478.1 flagellar hook-associated protein FlgK -
NL424_RS01400 (209069) 209069..210022 + 954 WP_001212768.1 flagellar hook-associated protein FlgL -
NL424_RS01405 (210117) 210117..210611 - 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
NL424_RS01410 (210608) 210608..210901 - 294 WP_001110447.1 DUF1778 domain-containing protein Antitoxin
NL424_RS01415 (211034) 211034..214219 - 3186 WP_001550951.1 ribonuclease E -
NL424_RS01420 (214792) 214792..215751 + 960 WP_000846342.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T269852 WP_000613626.1 NZ_CP117020:c210611-210117 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11109.69 Da        Isoelectric Point: 10.5423

>AT269852 WP_001110447.1 NZ_CP117020:c210901-210608 [Escherichia coli]
MPAANNIPTRRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0T0H9

Antitoxin

Source ID Structure
AlphaFold DB L4JCW6

References