Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4302691..4303309 Replicon chromosome
Accession NZ_CP117016
Organism Escherichia coli strain MLI121

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NL415_RS21555 Protein ID WP_001291435.1
Coordinates 4302691..4302909 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NL415_RS21560 Protein ID WP_000344800.1
Coordinates 4302935..4303309 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL415_RS21520 (4297980) 4297980..4298552 + 573 WP_000779831.1 YbaY family lipoprotein -
NL415_RS21525 (4298583) 4298583..4298894 - 312 WP_000409911.1 MGMT family protein -
NL415_RS21535 (4299273) 4299273..4299626 + 354 WP_000878140.1 DUF1428 domain-containing protein -
NL415_RS21540 (4299668) 4299668..4301218 - 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NL415_RS21545 (4301382) 4301382..4301852 - 471 WP_000136192.1 YlaC family protein -
NL415_RS21550 (4301968) 4301968..4302519 - 552 WP_000102564.1 maltose O-acetyltransferase -
NL415_RS21555 (4302691) 4302691..4302909 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NL415_RS21560 (4302935) 4302935..4303309 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NL415_RS21565 (4303855) 4303855..4307004 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
NL415_RS21570 (4307027) 4307027..4308220 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269844 WP_001291435.1 NZ_CP117016:c4302909-4302691 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269844 WP_000344800.1 NZ_CP117016:c4303309-4302935 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References