Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3615283..3616115 Replicon chromosome
Accession NZ_CP117016
Organism Escherichia coli strain MLI121

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag NL415_RS18285 Protein ID WP_000854765.1
Coordinates 3615741..3616115 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag NL415_RS18280 Protein ID WP_001295723.1
Coordinates 3615283..3615651 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL415_RS18255 (3612398) 3612398..3612593 + 196 Protein_3432 DUF905 family protein -
NL415_RS18260 (3612711) 3612711..3613529 + 819 WP_001234652.1 DUF932 domain-containing protein -
NL415_RS18265 (3613871) 3613871..3614344 + 474 WP_000855059.1 antirestriction protein -
NL415_RS18270 (3614360) 3614360..3614836 + 477 WP_001186775.1 RadC family protein -
NL415_RS18275 (3614899) 3614899..3615120 + 222 WP_000692345.1 DUF987 domain-containing protein -
NL415_RS18280 (3615283) 3615283..3615651 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NL415_RS18285 (3615741) 3615741..3616115 + 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
NL415_RS18290 (3616112) 3616112..3616603 + 492 WP_000976842.1 DUF5983 family protein -
NL415_RS18295 (3616620) 3616620..3616796 + 177 WP_000839290.1 DUF957 domain-containing protein -
NL415_RS18300 (3616902) 3616902..3617051 + 150 Protein_3441 hypothetical protein -
NL415_RS18305 (3617707) 3617707..3620598 + 2892 WP_000580534.1 SNF2-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T269841 WP_000854765.1 NZ_CP117016:3615741-3616115 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT269841 WP_001295723.1 NZ_CP117016:3615283-3615651 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7ZVJ9

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References