Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3522020..3522542 Replicon chromosome
Accession NZ_CP117016
Organism Escherichia coli strain MLI121

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag NL415_RS17795 Protein ID WP_001105433.1
Coordinates 3522252..3522542 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag NL415_RS17790 Protein ID WP_000212715.1
Coordinates 3522020..3522262 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL415_RS17770 (3517736) 3517736..3519109 + 1374 WP_001219792.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
NL415_RS17775 (3519261) 3519261..3519812 - 552 WP_000166295.1 ribosome biogenesis factor YjgA -
NL415_RS17780 (3519906) 3519906..3521258 + 1353 WP_001162171.1 metalloprotease PmbA -
NL415_RS17785 (3521442) 3521442..3521828 + 387 WP_001232246.1 cytochrome b562 -
NL415_RS17790 (3522020) 3522020..3522262 + 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NL415_RS17795 (3522252) 3522252..3522542 + 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL415_RS17800 (3522543) 3522543..3523007 - 465 WP_001106233.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NL415_RS17805 (3523165) 3523165..3525303 - 2139 WP_000187799.1 anaerobic ribonucleoside-triphosphate reductase -
NL415_RS17810 (3525697) 3525697..3527352 - 1656 WP_001392998.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T269840 WP_001105433.1 NZ_CP117016:3522252-3522542 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT269840 WP_000212715.1 NZ_CP117016:3522020-3522262 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References