Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3510406..3511001 Replicon chromosome
Accession NZ_CP117016
Organism Escherichia coli strain MLI121

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag NL415_RS17735 Protein ID WP_000239581.1
Coordinates 3510651..3511001 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag NL415_RS17730 Protein ID WP_001223213.1
Coordinates 3510406..3510657 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL415_RS17720 (3506071) 3506071..3509850 + 3780 WP_000060909.1 autotransporter assembly complex protein TamB -
NL415_RS17725 (3509853) 3509853..3510194 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NL415_RS17730 (3510406) 3510406..3510657 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NL415_RS17735 (3510651) 3510651..3511001 + 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
NL415_RS17740 (3511080) 3511080..3511610 - 531 WP_000055075.1 inorganic diphosphatase -
NL415_RS17745 (3511920) 3511920..3512876 + 957 WP_000265935.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NL415_RS17750 (3513009) 3513009..3514511 + 1503 WP_001024741.1 sugar ABC transporter ATP-binding protein -
NL415_RS17755 (3514525) 3514525..3515547 + 1023 WP_001468884.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T269839 WP_000239581.1 NZ_CP117016:3510651-3511001 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT269839 WP_001223213.1 NZ_CP117016:3510406-3510657 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References