Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4798635..4799132 Replicon chromosome
Accession NZ_CP117013
Organism Escherichia coli strain MLI114

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NL414_RS23970 Protein ID WP_001173343.1
Coordinates 4798635..4798808 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A2X1N3L1
Locus tag NL414_RS23975 Protein ID WP_001560287.1
Coordinates 4798836..4799132 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL414_RS23960 (4795305) 4795305..4796762 + 1458 WP_000856819.1 dipeptide/tripeptide permease DtpC -
NL414_RS23965 (4796999) 4796999..4798516 + 1518 WP_000003806.1 lysine--tRNA ligase -
NL414_RS23970 (4798635) 4798635..4798808 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NL414_RS23975 (4798836) 4798836..4799132 - 297 WP_001560287.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NL414_RS23980 (4799361) 4799361..4799633 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
NL414_RS23985 (4799645) 4799645..4799875 - 231 WP_000373291.1 4Fe-4S mono-cluster protein YjdI -
NL414_RS23990 (4800056) 4800056..4801687 + 1632 WP_001216477.1 sensor histidine kinase -
NL414_RS23995 (4801684) 4801684..4802403 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T269826 WP_001173343.1 NZ_CP117013:c4798808-4798635 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11441.94 Da        Isoelectric Point: 4.2924

>AT269826 WP_001560287.1 NZ_CP117013:c4799132-4798836 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMHDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1N3L1

References