Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4696569..4697164 Replicon chromosome
Accession NZ_CP117013
Organism Escherichia coli strain MLI114

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag NL414_RS23450 Protein ID WP_000239581.1
Coordinates 4696569..4696919 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag NL414_RS23455 Protein ID WP_001223213.1
Coordinates 4696913..4697164 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL414_RS23430 (4692023) 4692023..4693045 - 1023 WP_001468884.1 ABC transporter permease -
NL414_RS23435 (4693059) 4693059..4694561 - 1503 WP_001024741.1 sugar ABC transporter ATP-binding protein -
NL414_RS23440 (4694694) 4694694..4695650 - 957 WP_000265935.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NL414_RS23445 (4695960) 4695960..4696490 + 531 WP_000055075.1 inorganic diphosphatase -
NL414_RS23450 (4696569) 4696569..4696919 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
NL414_RS23455 (4696913) 4696913..4697164 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NL414_RS23460 (4697376) 4697376..4697717 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NL414_RS23465 (4697720) 4697720..4701499 - 3780 WP_000060909.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T269825 WP_000239581.1 NZ_CP117013:c4696919-4696569 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT269825 WP_001223213.1 NZ_CP117013:c4697164-4696913 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References