Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4685028..4685550 Replicon chromosome
Accession NZ_CP117013
Organism Escherichia coli strain MLI114

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag NL414_RS23390 Protein ID WP_001105433.1
Coordinates 4685028..4685318 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag NL414_RS23395 Protein ID WP_000212715.1
Coordinates 4685308..4685550 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL414_RS23375 (4680218) 4680218..4681873 + 1656 WP_001392998.1 alpha,alpha-phosphotrehalase -
NL414_RS23380 (4682267) 4682267..4684405 + 2139 WP_000187799.1 anaerobic ribonucleoside-triphosphate reductase -
NL414_RS23385 (4684563) 4684563..4685027 + 465 WP_001106233.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NL414_RS23390 (4685028) 4685028..4685318 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL414_RS23395 (4685308) 4685308..4685550 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NL414_RS23400 (4685742) 4685742..4686128 - 387 WP_001232246.1 cytochrome b562 -
NL414_RS23405 (4686312) 4686312..4687664 - 1353 WP_001162171.1 metalloprotease PmbA -
NL414_RS23410 (4687758) 4687758..4688309 + 552 WP_000166295.1 ribosome biogenesis factor YjgA -
NL414_RS23415 (4688461) 4688461..4689834 - 1374 WP_001219792.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T269824 WP_001105433.1 NZ_CP117013:c4685318-4685028 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT269824 WP_000212715.1 NZ_CP117013:c4685550-4685308 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References