Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3904260..3904878 Replicon chromosome
Accession NZ_CP117013
Organism Escherichia coli strain MLI114

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NL414_RS19625 Protein ID WP_001291435.1
Coordinates 3904660..3904878 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NL414_RS19620 Protein ID WP_000344800.1
Coordinates 3904260..3904634 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL414_RS19610 (3899349) 3899349..3900542 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL414_RS19615 (3900565) 3900565..3903714 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
NL414_RS19620 (3904260) 3904260..3904634 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NL414_RS19625 (3904660) 3904660..3904878 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NL414_RS19630 (3905050) 3905050..3905601 + 552 WP_000102564.1 maltose O-acetyltransferase -
NL414_RS19635 (3905717) 3905717..3906187 + 471 WP_000136192.1 YlaC family protein -
NL414_RS19640 (3906351) 3906351..3907901 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NL414_RS19645 (3907943) 3907943..3908296 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NL414_RS19655 (3908675) 3908675..3908986 + 312 WP_000409911.1 MGMT family protein -
NL414_RS19660 (3909017) 3909017..3909589 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269820 WP_001291435.1 NZ_CP117013:3904660-3904878 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269820 WP_000344800.1 NZ_CP117013:3904260-3904634 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References