Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 159942..160554 Replicon chromosome
Accession NZ_CP117013
Organism Escherichia coli strain MLI114

Toxin (Protein)


Gene name hicA Uniprot ID A0A167AMN3
Locus tag NL414_RS01180 Protein ID WP_000833474.1
Coordinates 159942..160127 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1V3VHB3
Locus tag NL414_RS01185 Protein ID WP_000499746.1
Coordinates 160144..160554 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL414_RS01165 (155459) 155459..156610 + 1152 WP_000741506.1 L-threonine dehydrogenase -
NL414_RS01170 (156811) 156811..158349 + 1539 WP_001469350.1 aldehyde dehydrogenase AldB -
NL414_RS01175 (158390) 158390..159469 - 1080 WP_000061479.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
NL414_RS01180 (159942) 159942..160127 + 186 WP_000833474.1 type II toxin-antitoxin system HicA family toxin Toxin
NL414_RS01185 (160144) 160144..160554 + 411 WP_000499746.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NL414_RS01190 (160626) 160626..162590 - 1965 WP_001026871.1 glycoside hydrolase family 127 protein -
NL414_RS01195 (162601) 162601..164001 - 1401 WP_000204815.1 MFS transporter -
NL414_RS01200 (164227) 164227..165042 + 816 WP_000891838.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6819.94 Da        Isoelectric Point: 12.0345

>T269808 WP_000833474.1 NZ_CP117013:159942-160127 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSRHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15290.22 Da        Isoelectric Point: 4.5486

>AT269808 WP_000499746.1 NZ_CP117013:160144-160554 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDYAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A167AMN3

Antitoxin

Source ID Structure
AlphaFold DB A0A1V3VHB3

References