269803

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4174189..4174686 Replicon chromosome
Accession NZ_CP117010
Organism Escherichia coli strain MLI110

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NL413_RS20920 Protein ID WP_001173343.1
Coordinates 4174189..4174362 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag NL413_RS20925 Protein ID WP_000398619.1
Coordinates 4174390..4174686 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL413_RS20910 (4170859) 4170859..4172316 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
NL413_RS20915 (4172553) 4172553..4174070 + 1518 WP_001295074.1 lysine--tRNA ligase -
NL413_RS20920 (4174189) 4174189..4174362 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NL413_RS20925 (4174390) 4174390..4174686 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NL413_RS20930 (4174913) 4174913..4175185 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
NL413_RS20935 (4175197) 4175197..4175427 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
NL413_RS20940 (4175608) 4175608..4177239 + 1632 WP_001216477.1 sensor histidine kinase -
NL413_RS20945 (4177236) 4177236..4177955 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T269803 WP_001173343.1 NZ_CP117010:c4174362-4174189 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT269803 WP_000398619.1 NZ_CP117010:c4174686-4174390 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References