Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2156618..2157256 Replicon chromosome
Accession NZ_CP117010
Organism Escherichia coli strain MLI110

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NL413_RS11100 Protein ID WP_000813794.1
Coordinates 2156618..2156794 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NL413_RS11105 Protein ID WP_001270286.1
Coordinates 2156840..2157256 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL413_RS11080 (2152237) 2152237..2153412 - 1176 WP_001236251.1 BenE family transporter YdcO -
NL413_RS11085 (2153504) 2153504..2154040 + 537 WP_000429133.1 DNA-binding transcriptional regulator SutR -
NL413_RS11090 (2154113) 2154113..2156074 + 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NL413_RS11095 (2156166) 2156166..2156396 - 231 WP_000494244.1 YncJ family protein -
NL413_RS11100 (2156618) 2156618..2156794 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NL413_RS11105 (2156840) 2156840..2157256 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NL413_RS11110 (2157335) 2157335..2158741 + 1407 WP_000760585.1 PLP-dependent aminotransferase family protein -
NL413_RS11115 (2158986) 2158986..2160131 + 1146 WP_257812150.1 ABC transporter substrate-binding protein -
NL413_RS11120 (2160149) 2160149..2161162 + 1014 WP_000220399.1 ABC transporter ATP-binding protein -
NL413_RS11125 (2161163) 2161163..2162104 + 942 WP_001251313.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2150932..2152197 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T269794 WP_000813794.1 NZ_CP117010:2156618-2156794 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT269794 WP_001270286.1 NZ_CP117010:2156840-2157256 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References