Detailed information of TA system TA269781

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4065764..4067453
• Replicon: chromosome
• Accession: NZ_CP117008
• Organism: Escherichia coli strain MLI109

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: V0Z9M0
• Locus tag: NL412_RS20715
• Protein ID: WP_000365809.1
• Coordinates: 4065764..4066684 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: NL412_RS20720
• Protein ID: WP_001550661.1
• Coordinates: 4066671..4067453 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NL412_RS20700 (4061854)	4061854..4062981	-	1128	WP_001550663.1	MFS transporter	-
NL412_RS20705 (4063123)	4063123..4064181	-	1059	WP_122987197.1	alpha/beta hydrolase	-
NL412_RS20710 (4064446)	4064446..4065330	+	885	WP_001119037.1	LysR family transcriptional regulator	-
NL412_RS20715 (4065764)	4065764..4066684	-	921	WP_000365809.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NL412_RS20720 (4066671)	4066671..4067453	-	783	WP_001550661.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
NL412_RS20725 (4067769)	4067769..4070978	+	3210	WP_001521910.1	RNA-directed DNA polymerase	-
NL412_RS20730 (4071325)	4071325..4071795	+	471	WP_000201185.1	hypothetical protein	-
NL412_RS20735 (4071792)	4071792..4071894	+	103	Protein_3894	helix-turn-helix domain-containing protein	-
NL412_RS20740 (4071986)	4071986..4072144	+	159	Protein_3895	integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-261)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-247)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34571.01 Da
• Isoelectric Point: 7.2649

>T269781 WP_000365809.1 NZ_CP117008:c4066684-4065764 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29191.43 Da
• Isoelectric Point: 8.9059

>AT269781 WP_001550661.1 NZ_CP117008:c4067453-4066671 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: V0Z9M0