Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2435635..2436273 Replicon chromosome
Accession NZ_CP117008
Organism Escherichia coli strain MLI109

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag NL412_RS12725 Protein ID WP_000813795.1
Coordinates 2435635..2435811 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NL412_RS12730 Protein ID WP_076797675.1
Coordinates 2435857..2436273 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL412_RS12705 (2431257) 2431257..2432429 - 1173 WP_001551088.1 BenE family transporter YdcO -
NL412_RS12710 (2432521) 2432521..2433057 + 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
NL412_RS12715 (2433130) 2433130..2435091 + 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NL412_RS12720 (2435183) 2435183..2435413 - 231 WP_023910283.1 YncJ family protein -
NL412_RS12725 (2435635) 2435635..2435811 + 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NL412_RS12730 (2435857) 2435857..2436273 + 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NL412_RS12735 (2436352) 2436352..2437758 + 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
NL412_RS12740 (2438003) 2438003..2439148 + 1146 WP_001551094.1 ABC transporter substrate-binding protein -
NL412_RS12745 (2439166) 2439166..2440179 + 1014 WP_001551095.1 ABC transporter ATP-binding protein -
NL412_RS12750 (2440180) 2440180..2441121 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T269772 WP_000813795.1 NZ_CP117008:2435635-2435811 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT269772 WP_076797675.1 NZ_CP117008:2435857-2436273 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References