Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 975965..976619 Replicon chromosome
Accession NZ_CP117008
Organism Escherichia coli strain MLI109

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NL412_RS05540 Protein ID WP_000244781.1
Coordinates 976212..976619 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag NL412_RS05535 Protein ID WP_001564007.1
Coordinates 975965..976231 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL412_RS05515 (972053) 972053..973486 - 1434 WP_001564009.1 6-phospho-beta-glucosidase BglA -
NL412_RS05520 (973531) 973531..973842 + 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
NL412_RS05525 (974006) 974006..974665 + 660 WP_000250274.1 hemolysin III family protein -
NL412_RS05530 (974742) 974742..975722 - 981 WP_001564008.1 tRNA-modifying protein YgfZ -
NL412_RS05535 (975965) 975965..976231 + 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
NL412_RS05540 (976212) 976212..976619 + 408 WP_000244781.1 protein YgfX Toxin
NL412_RS05545 (976659) 976659..977180 - 522 WP_001055874.1 flavodoxin FldB -
NL412_RS05550 (977292) 977292..978188 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NL412_RS05555 (978213) 978213..978923 + 711 WP_001564005.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NL412_RS05560 (978929) 978929..980662 + 1734 WP_001564004.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T269767 WP_000244781.1 NZ_CP117008:976212-976619 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT269767 WP_001564007.1 NZ_CP117008:975965-976231 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References