Detailed information of TA system TA269752

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3813784..3815473
• Replicon: chromosome
• Accession: NZ_CP117006
• Organism: Escherichia coli strain MLI108K3

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: V0Z9M0
• Locus tag: NL411_RS20055
• Protein ID: WP_000365809.1
• Coordinates: 3813784..3814704 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: NL411_RS20060
• Protein ID: WP_001550661.1
• Coordinates: 3814691..3815473 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NL411_RS20040 (3809874)	3809874..3811001	-	1128	WP_001550663.1	MFS transporter	-
NL411_RS20045 (3811143)	3811143..3812201	-	1059	WP_122987197.1	alpha/beta hydrolase	-
NL411_RS20050 (3812466)	3812466..3813350	+	885	WP_001119037.1	LysR family transcriptional regulator	-
NL411_RS20055 (3813784)	3813784..3814704	-	921	WP_000365809.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NL411_RS20060 (3814691)	3814691..3815473	-	783	WP_001550661.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
NL411_RS20065 (3815789)	3815789..3818998	+	3210	WP_001521910.1	RNA-directed DNA polymerase	-
NL411_RS20070 (3819345)	3819345..3819815	+	471	WP_000201185.1	hypothetical protein	-
NL411_RS20075 (3819812)	3819812..3819914	+	103	Protein_3610	helix-turn-helix domain-containing protein	-
NL411_RS20080 (3820006)	3820006..3820164	+	159	Protein_3611	integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3812466..3866234	53768

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-261)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-247)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34571.01 Da
• Isoelectric Point: 7.2649

>T269752 WP_000365809.1 NZ_CP117006:c3814704-3813784 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29191.43 Da
• Isoelectric Point: 8.9059

>AT269752 WP_001550661.1 NZ_CP117006:c3815473-3814691 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: V0Z9M0