Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3610297..3610915 Replicon chromosome
Accession NZ_CP117006
Organism Escherichia coli strain MLI108K3

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NL411_RS19110 Protein ID WP_001291435.1
Coordinates 3610697..3610915 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NL411_RS19105 Protein ID WP_000344800.1
Coordinates 3610297..3610671 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL411_RS19095 (3605386) 3605386..3606579 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL411_RS19100 (3606602) 3606602..3609751 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
NL411_RS19105 (3610297) 3610297..3610671 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NL411_RS19110 (3610697) 3610697..3610915 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NL411_RS19115 (3611087) 3611087..3611638 + 552 WP_000102564.1 maltose O-acetyltransferase -
NL411_RS19120 (3611754) 3611754..3612224 + 471 WP_000136192.1 YlaC family protein -
NL411_RS19125 (3612388) 3612388..3613938 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NL411_RS19130 (3613980) 3613980..3614333 - 354 WP_001550741.1 DUF1428 family protein -
NL411_RS19140 (3614712) 3614712..3615023 + 312 WP_000409911.1 MGMT family protein -
NL411_RS19145 (3615054) 3615054..3615626 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269751 WP_001291435.1 NZ_CP117006:3610697-3610915 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269751 WP_000344800.1 NZ_CP117006:3610297-3610671 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References