Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3151288..3151993 Replicon chromosome
Accession NZ_CP117006
Organism Escherichia coli strain MLI108K3

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag NL411_RS16965 Protein ID WP_000539521.1
Coordinates 3151288..3151674 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NL411_RS16970 Protein ID WP_001280945.1
Coordinates 3151664..3151993 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL411_RS16945 (3147292) 3147292..3147918 + 627 WP_001595548.1 glutathione S-transferase GstB -
NL411_RS16950 (3147915) 3147915..3149030 - 1116 WP_001595547.1 aldose sugar dehydrogenase YliI -
NL411_RS16955 (3149141) 3149141..3149524 - 384 WP_000497137.1 biofilm formation regulator BssR -
NL411_RS16960 (3149737) 3149737..3151062 + 1326 WP_000049378.1 30S ribosomal protein S12 methylthiotransferase RimO -
NL411_RS16965 (3151288) 3151288..3151674 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL411_RS16970 (3151664) 3151664..3151993 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
NL411_RS16975 (3152063) 3152063..3153391 - 1329 WP_049068068.1 GGDEF domain-containing protein -
NL411_RS16980 (3153399) 3153399..3155747 - 2349 WP_001328220.1 EAL domain-containing protein -
NL411_RS16985 (3155925) 3155925..3156836 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T269750 WP_000539521.1 NZ_CP117006:3151288-3151674 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT269750 WP_001280945.1 NZ_CP117006:3151664-3151993 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References