Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 929512..930172 Replicon chromosome
Accession NZ_CP117006
Organism Escherichia coli strain MLI108K3

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag NL411_RS06105 Protein ID WP_029701967.1
Coordinates 929759..930172 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NL411_RS06100 Protein ID WP_000354046.1
Coordinates 929512..929778 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL411_RS06075 (924800) 924800..925543 + 744 WP_000951964.1 SDR family oxidoreductase -
NL411_RS06080 (925600) 925600..927033 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
NL411_RS06085 (927078) 927078..927389 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
NL411_RS06090 (927553) 927553..928212 + 660 WP_000250274.1 hemolysin III family protein -
NL411_RS06095 (928289) 928289..929269 - 981 WP_000886083.1 tRNA-modifying protein YgfZ -
NL411_RS06100 (929512) 929512..929778 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NL411_RS06105 (929759) 929759..930172 + 414 WP_029701967.1 protein YgfX Toxin
NL411_RS06110 (930206) 930206..930727 - 522 WP_001055874.1 flavodoxin FldB -
NL411_RS06115 (930839) 930839..931735 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NL411_RS06120 (931759) 931759..932469 + 711 WP_029701969.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NL411_RS06125 (932475) 932475..934208 + 1734 WP_029701971.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16305.25 Da        Isoelectric Point: 11.7064

>T269738 WP_029701967.1 NZ_CP117006:929759-930172 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLLHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQRSR

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT269738 WP_000354046.1 NZ_CP117006:929512-929778 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References