Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4266958..4267576 Replicon chromosome
Accession NZ_CP117001
Organism Escherichia coli strain MLI108K2

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NL410_RS22660 Protein ID WP_001291435.1
Coordinates 4266958..4267176 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NL410_RS22665 Protein ID WP_000344800.1
Coordinates 4267202..4267576 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL410_RS22625 (4262247) 4262247..4262819 + 573 WP_000779831.1 YbaY family lipoprotein -
NL410_RS22630 (4262850) 4262850..4263161 - 312 WP_000409911.1 MGMT family protein -
NL410_RS22640 (4263540) 4263540..4263893 + 354 WP_000878140.1 DUF1428 domain-containing protein -
NL410_RS22645 (4263935) 4263935..4265485 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NL410_RS22650 (4265649) 4265649..4266119 - 471 WP_000136192.1 YlaC family protein -
NL410_RS22655 (4266235) 4266235..4266786 - 552 WP_000102564.1 maltose O-acetyltransferase -
NL410_RS22660 (4266958) 4266958..4267176 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NL410_RS22665 (4267202) 4267202..4267576 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NL410_RS22670 (4268122) 4268122..4271271 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NL410_RS22675 (4271294) 4271294..4272487 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269727 WP_001291435.1 NZ_CP117001:c4267176-4266958 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269727 WP_000344800.1 NZ_CP117001:c4267576-4267202 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References