Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | chpSB/PRK09812-ChpS |
Location | 3595784..3596379 | Replicon | chromosome |
Accession | NZ_CP117001 | ||
Organism | Escherichia coli strain MLI108K2 |
Toxin (Protein)
Gene name | chpB | Uniprot ID | U9Y4M4 |
Locus tag | NL410_RS19395 | Protein ID | WP_000239579.1 |
Coordinates | 3596029..3596379 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | chpS | Uniprot ID | U9Y2K1 |
Locus tag | NL410_RS19390 | Protein ID | WP_001223208.1 |
Coordinates | 3595784..3596035 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NL410_RS19380 (3591448) | 3591448..3595227 | + | 3780 | WP_000060921.1 | autotransporter assembly complex protein TamB | - |
NL410_RS19385 (3595230) | 3595230..3595571 | + | 342 | WP_001219160.1 | gamma-glutamylcyclotransferase | - |
NL410_RS19390 (3595784) | 3595784..3596035 | + | 252 | WP_001223208.1 | type II toxin-antitoxin system antitoxin ChpS | Antitoxin |
NL410_RS19395 (3596029) | 3596029..3596379 | + | 351 | WP_000239579.1 | endoribonuclease toxin ChpB | Toxin |
NL410_RS19400 (3596459) | 3596459..3596989 | - | 531 | WP_000055072.1 | inorganic diphosphatase | - |
NL410_RS19405 (3597299) | 3597299..3598255 | + | 957 | WP_000265933.1 | galactofuranose ABC transporter substrate-binding protein YtfQ | - |
NL410_RS19410 (3598565) | 3598565..3600067 | + | 1503 | WP_000205791.1 | sugar ABC transporter ATP-binding protein | - |
NL410_RS19415 (3600081) | 3600081..3601103 | + | 1023 | WP_024198507.1 | ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12511.45 Da Isoelectric Point: 5.6219
>T269722 WP_000239579.1 NZ_CP117001:3596029-3596379 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE
Download Length: 351 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0Y8A8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LQ26 |