Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 1699372..1699997 | Replicon | chromosome |
Accession | NZ_CP117001 | ||
Organism | Escherichia coli strain MLI108K2 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | U9YZ02 |
Locus tag | NL410_RS10250 | Protein ID | WP_000911329.1 |
Coordinates | 1699372..1699770 (-) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | U9XQV3 |
Locus tag | NL410_RS10255 | Protein ID | WP_000450524.1 |
Coordinates | 1699770..1699997 (-) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NL410_RS10230 (1695250) | 1695250..1695450 | + | 201 | WP_000383836.1 | YpfN family protein | - |
NL410_RS10235 (1695560) | 1695560..1696258 | - | 699 | WP_000679812.1 | esterase | - |
NL410_RS10240 (1696332) | 1696332..1698347 | - | 2016 | WP_000829332.1 | tRNA cytosine(34) acetyltransferase TmcA | - |
NL410_RS10245 (1698362) | 1698362..1699225 | - | 864 | WP_001267507.1 | neutral zinc metallopeptidase | - |
NL410_RS10250 (1699372) | 1699372..1699770 | - | 399 | WP_000911329.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
NL410_RS10255 (1699770) | 1699770..1699997 | - | 228 | WP_000450524.1 | toxin-antitoxin system antitoxin VapB | Antitoxin |
NL410_RS10260 (1700153) | 1700153..1700866 | - | 714 | WP_001295467.1 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | - |
NL410_RS10265 (1701079) | 1701079..1702113 | - | 1035 | WP_001297320.1 | outer membrane protein assembly factor BamC | - |
NL410_RS10270 (1702130) | 1702130..1703008 | - | 879 | WP_001295469.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
NL410_RS10275 (1703154) | 1703154..1703726 | + | 573 | WP_000176187.1 | glycine cleavage system transcriptional repressor | - |
NL410_RS10280 (1703726) | 1703726..1704196 | + | 471 | WP_001068682.1 | thioredoxin-dependent thiol peroxidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14924.23 Da Isoelectric Point: 8.5325
>T269717 WP_000911329.1 NZ_CP117001:c1699770-1699372 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS
Download Length: 399 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0XW84 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CM33 |