269710

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 760573..761099 Replicon chromosome
Accession NZ_CP117001
Organism Escherichia coli strain MLI108K2

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag NL410_RS05615 Protein ID WP_000323025.1
Coordinates 760573..760860 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag NL410_RS05620 Protein ID WP_000534858.1
Coordinates 760860..761099 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL410_RS05565 (755597) 755597..755812 - 216 WP_000839590.1 phage lysis protein EssD -
NL410_RS05570 (756032) 756032..756202 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
NL410_RS05575 (756566) 756566..756781 - 216 WP_000066484.1 cold shock-like protein CspB -
NL410_RS05580 (757082) 757082..757294 + 213 WP_000087756.1 cold shock-like protein CspF -
NL410_RS05585 (757349) 757349..757438 + 90 WP_120795389.1 hypothetical protein -
NL410_RS05590 (757716) 757716..758468 - 753 WP_001047135.1 antitermination protein -
NL410_RS05595 (758482) 758482..759531 - 1050 WP_001265199.1 DUF968 domain-containing protein -
NL410_RS05600 (759533) 759533..759811 - 279 WP_012304870.1 hypothetical protein -
NL410_RS05605 (759878) 759878..760129 - 252 WP_000980994.1 protein Rem -
NL410_RS05610 (760346) 760346..760501 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
NL410_RS05615 (760573) 760573..760860 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
NL410_RS05620 (760860) 760860..761099 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
NL410_RS05625 (761124) 761124..761429 + 306 WP_001326990.1 protein YdfV -
NL410_RS05630 (761632) 761632..761964 + 333 WP_001301033.1 FlxA-like family protein -
NL410_RS05635 (762401) 762401..762550 - 150 WP_011443592.1 protein YdfW -
NL410_RS05640 (762671) 762671..763693 - 1023 Protein_766 ISNCY family transposase -
NL410_RS05645 (764483) 764483..764770 - 288 Protein_767 hypothetical protein -
NL410_RS05650 (764992) 764992..765396 + 405 WP_000839179.1 transposase -
NL410_RS05655 (765393) 765393..765740 + 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 725458..788434 62976


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T269710 WP_000323025.1 NZ_CP117001:c760860-760573 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT269710 WP_000534858.1 NZ_CP117001:c761099-760860 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References