Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4266322..4266940 Replicon chromosome
Accession NZ_CP116994
Organism Escherichia coli strain MLI108K1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NL409_RS22645 Protein ID WP_001291435.1
Coordinates 4266322..4266540 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NL409_RS22650 Protein ID WP_000344800.1
Coordinates 4266566..4266940 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL409_RS22610 (4261611) 4261611..4262183 + 573 WP_000779831.1 YbaY family lipoprotein -
NL409_RS22615 (4262214) 4262214..4262525 - 312 WP_000409911.1 MGMT family protein -
NL409_RS22625 (4262904) 4262904..4263257 + 354 WP_000878140.1 DUF1428 domain-containing protein -
NL409_RS22630 (4263299) 4263299..4264849 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NL409_RS22635 (4265013) 4265013..4265483 - 471 WP_000136192.1 YlaC family protein -
NL409_RS22640 (4265599) 4265599..4266150 - 552 WP_000102564.1 maltose O-acetyltransferase -
NL409_RS22645 (4266322) 4266322..4266540 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NL409_RS22650 (4266566) 4266566..4266940 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NL409_RS22655 (4267486) 4267486..4270635 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NL409_RS22660 (4270658) 4270658..4271851 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269696 WP_001291435.1 NZ_CP116994:c4266540-4266322 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269696 WP_000344800.1 NZ_CP116994:c4266940-4266566 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References