Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3709919..3710751 Replicon chromosome
Accession NZ_CP116994
Organism Escherichia coli strain MLI108K1

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag NL409_RS19995 Protein ID WP_000854765.1
Coordinates 3710377..3710751 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag NL409_RS19990 Protein ID WP_001295723.1
Coordinates 3709919..3710287 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL409_RS19965 (3707034) 3707034..3707229 + 196 Protein_3550 DUF905 family protein -
NL409_RS19970 (3707347) 3707347..3708165 + 819 WP_046464190.1 DUF932 domain-containing protein -
NL409_RS19975 (3708507) 3708507..3708980 + 474 WP_000855059.1 antirestriction protein -
NL409_RS19980 (3708996) 3708996..3709472 + 477 WP_001186774.1 RadC family protein -
NL409_RS19985 (3709535) 3709535..3709756 + 222 WP_000692345.1 DUF987 domain-containing protein -
NL409_RS19990 (3709919) 3709919..3710287 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NL409_RS19995 (3710377) 3710377..3710751 + 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
NL409_RS20000 (3710748) 3710748..3711239 + 492 WP_000976842.1 DUF5983 family protein -
NL409_RS20005 (3711256) 3711256..3711432 + 177 WP_000839290.1 DUF957 domain-containing protein -
NL409_RS20010 (3711538) 3711538..3711687 + 150 Protein_3559 hypothetical protein -
NL409_RS20015 (3712178) 3712178..3715294 - 3117 WP_000149665.1 HsdR family type I site-specific deoxyribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T269692 WP_000854765.1 NZ_CP116994:3710377-3710751 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT269692 WP_001295723.1 NZ_CP116994:3709919-3710287 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7ZVJ9

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References