Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1698616..1699241 Replicon chromosome
Accession NZ_CP116994
Organism Escherichia coli strain MLI108K1

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag NL409_RS10235 Protein ID WP_000911329.1
Coordinates 1698616..1699014 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NL409_RS10240 Protein ID WP_000450524.1
Coordinates 1699014..1699241 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL409_RS10215 (1694494) 1694494..1694694 + 201 WP_000383836.1 YpfN family protein -
NL409_RS10220 (1694804) 1694804..1695502 - 699 WP_000679812.1 esterase -
NL409_RS10225 (1695576) 1695576..1697591 - 2016 WP_000829332.1 tRNA cytosine(34) acetyltransferase TmcA -
NL409_RS10230 (1697606) 1697606..1698469 - 864 WP_001267507.1 neutral zinc metallopeptidase -
NL409_RS10235 (1698616) 1698616..1699014 - 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
NL409_RS10240 (1699014) 1699014..1699241 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NL409_RS10245 (1699397) 1699397..1700110 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NL409_RS10250 (1700323) 1700323..1701357 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NL409_RS10255 (1701374) 1701374..1702252 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NL409_RS10260 (1702398) 1702398..1702970 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NL409_RS10265 (1702970) 1702970..1703440 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T269686 WP_000911329.1 NZ_CP116994:c1699014-1698616 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT269686 WP_000450524.1 NZ_CP116994:c1699241-1699014 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References