Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4213945..4214540 Replicon chromosome
Accession NZ_CP116987
Organism Escherichia coli strain MLI107

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NL408_RS20490 Protein ID WP_000239579.1
Coordinates 4213945..4214295 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A4D0VVQ9
Locus tag NL408_RS20495 Protein ID WP_001223207.1
Coordinates 4214289..4214540 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL408_RS20470 (4209221) 4209221..4210243 - 1023 WP_001296689.1 ABC transporter permease -
NL408_RS20475 (4210257) 4210257..4211759 - 1503 WP_000205795.1 sugar ABC transporter ATP-binding protein -
NL408_RS20480 (4212069) 4212069..4213025 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NL408_RS20485 (4213335) 4213335..4213865 + 531 WP_000055072.1 inorganic diphosphatase -
NL408_RS20490 (4213945) 4213945..4214295 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NL408_RS20495 (4214289) 4214289..4214540 - 252 WP_001223207.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NL408_RS20500 (4214753) 4214753..4215094 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NL408_RS20505 (4215097) 4215097..4218876 - 3780 WP_000060927.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T269663 WP_000239579.1 NZ_CP116987:c4214295-4213945 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9285.61 Da        Isoelectric Point: 4.4201

>AT269663 WP_001223207.1 NZ_CP116987:c4214540-4214289 [Escherichia coli]
MRITIKRWGNSAGMVIPNILMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A4D0VVQ9

References