Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3713676..3714365 Replicon chromosome
Accession NZ_CP116987
Organism Escherichia coli strain MLI107

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag NL408_RS18190 Protein ID WP_206311470.1
Coordinates 3713676..3714014 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag NL408_RS18195 Protein ID WP_206311471.1
Coordinates 3714039..3714365 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL408_RS18175 (3710689) 3710689..3711645 + 957 WP_000121330.1 molybdenum cofactor insertion chaperone PaoD -
NL408_RS18180 (3711696) 3711696..3712034 + 339 Protein_3558 LysR substrate-binding domain-containing protein -
NL408_RS18185 (3712535) 3712535..3713284 - 750 WP_206311469.1 hypothetical protein -
NL408_RS18190 (3713676) 3713676..3714014 - 339 WP_206311470.1 TA system toxin CbtA family protein Toxin
NL408_RS18195 (3714039) 3714039..3714365 - 327 WP_206311471.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NL408_RS18200 (3714408) 3714408..3714887 - 480 WP_206311472.1 DNA repair protein RadC -
NL408_RS18205 (3714900) 3714900..3715364 - 465 WP_206311473.1 antirestriction protein -
NL408_RS18210 (3715425) 3715425..3716243 - 819 WP_206311474.1 DUF932 domain-containing protein -
NL408_RS18215 (3716705) 3716705..3717328 + 624 WP_206311475.1 inovirus Gp2 family protein -
NL408_RS18220 (3717433) 3717433..3717663 + 231 WP_206311486.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE 3686959..3731581 44622


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12840.78 Da        Isoelectric Point: 9.1652

>T269660 WP_206311470.1 NZ_CP116987:c3714014-3713676 [Escherichia coli]
MKTLPANQRVAKPCPPPVLVWQTLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLADAVNFLVEKYELVRIDRRGFN
CQEQSPYLRAVDILRARQATGLLRQRHHPSAR

Download         Length: 339 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12413.94 Da        Isoelectric Point: 6.0532

>AT269660 WP_206311471.1 NZ_CP116987:c3714365-3714039 [Escherichia coli]
MEKHDNPEWGLRCDVMPRFSARLVQESNRLHYLADRAGITGAFEEEECHQLNSAFPHFTEQMELMLLSGELNPRHAHRVT
LYHAGLSCEADTLGSHGYVYIAIYPTQR

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References