Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3517834..3518452 Replicon chromosome
Accession NZ_CP116987
Organism Escherichia coli strain MLI107

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NL408_RS17285 Protein ID WP_001291435.1
Coordinates 3518234..3518452 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NL408_RS17280 Protein ID WP_000344800.1
Coordinates 3517834..3518208 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL408_RS17270 (3512923) 3512923..3514116 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL408_RS17275 (3514139) 3514139..3517288 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NL408_RS17280 (3517834) 3517834..3518208 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NL408_RS17285 (3518234) 3518234..3518452 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NL408_RS17290 (3518623) 3518623..3519174 + 552 WP_000102578.1 maltose O-acetyltransferase -
NL408_RS17295 (3519290) 3519290..3519760 + 471 WP_000136192.1 YlaC family protein -
NL408_RS17300 (3519924) 3519924..3521474 + 1551 WP_001365886.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NL408_RS17305 (3521516) 3521516..3521869 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NL408_RS17315 (3522248) 3522248..3522559 + 312 WP_000409911.1 MGMT family protein -
NL408_RS17320 (3522590) 3522590..3523162 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269658 WP_001291435.1 NZ_CP116987:3518234-3518452 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269658 WP_000344800.1 NZ_CP116987:3517834-3518208 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References