Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1297662..1298287 Replicon chromosome
Accession NZ_CP116987
Organism Escherichia coli strain MLI107

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag NL408_RS06280 Protein ID WP_000911329.1
Coordinates 1297889..1298287 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NL408_RS06275 Protein ID WP_000450524.1
Coordinates 1297662..1297889 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL408_RS06250 (1293464) 1293464..1293934 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
NL408_RS06255 (1293934) 1293934..1294506 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NL408_RS06260 (1294652) 1294652..1295530 + 879 WP_001311023.1 4-hydroxy-tetrahydrodipicolinate synthase -
NL408_RS06265 (1295547) 1295547..1296581 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NL408_RS06270 (1296794) 1296794..1297507 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NL408_RS06275 (1297662) 1297662..1297889 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NL408_RS06280 (1297889) 1297889..1298287 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
NL408_RS06285 (1298434) 1298434..1299297 + 864 WP_001267498.1 neutral zinc metallopeptidase -
NL408_RS06290 (1299312) 1299312..1301327 + 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
NL408_RS06295 (1301401) 1301401..1302099 + 699 WP_000679823.1 esterase -
NL408_RS06300 (1302209) 1302209..1302409 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T269651 WP_000911329.1 NZ_CP116987:1297889-1298287 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT269651 WP_000450524.1 NZ_CP116987:1297662-1297889 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References