Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870191..870845 Replicon chromosome
Accession NZ_CP116987
Organism Escherichia coli strain MLI107

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag NL408_RS04260 Protein ID WP_000244772.1
Coordinates 870438..870845 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NL408_RS04255 Protein ID WP_000354046.1
Coordinates 870191..870457 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL408_RS04230 (865479) 865479..866222 + 744 WP_000951964.1 SDR family oxidoreductase -
NL408_RS04235 (866279) 866279..867712 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
NL408_RS04240 (867757) 867757..868068 + 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
NL408_RS04245 (868232) 868232..868891 + 660 WP_000250274.1 hemolysin III family protein -
NL408_RS04250 (868968) 868968..869948 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
NL408_RS04255 (870191) 870191..870457 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NL408_RS04260 (870438) 870438..870845 + 408 WP_000244772.1 protein YgfX Toxin
NL408_RS04265 (870885) 870885..871406 - 522 WP_001055874.1 flavodoxin FldB -
NL408_RS04270 (871518) 871518..872414 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NL408_RS04275 (872439) 872439..873149 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NL408_RS04280 (873155) 873155..874888 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T269649 WP_000244772.1 NZ_CP116987:870438-870845 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT269649 WP_000354046.1 NZ_CP116987:870191-870457 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References