Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 283416..284002 Replicon chromosome
Accession NZ_CP116987
Organism Escherichia coli strain MLI107

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag NL408_RS01280 Protein ID WP_042014162.1
Coordinates 283416..283646 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag NL408_RS01285 Protein ID WP_000593555.1
Coordinates 283643..284002 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL408_RS01270 (279453) 279453..282188 + 2736 WP_000149168.1 ribosome-associated ATPase/putative transporter RbbA -
NL408_RS01275 (282188) 282188..283312 + 1125 WP_001314210.1 ABC transporter permease -
NL408_RS01280 (283416) 283416..283646 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
NL408_RS01285 (283643) 283643..284002 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NL408_RS01290 (284122) 284122..284523 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
NL408_RS01295 (284529) 284529..285335 - 807 WP_000173667.1 nickel import ATP-binding protein NikE -
NL408_RS01300 (285332) 285332..286096 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
NL408_RS01305 (286096) 286096..286929 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
NL408_RS01310 (286926) 286926..287870 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T269646 WP_042014162.1 NZ_CP116987:283416-283646 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT269646 WP_000593555.1 NZ_CP116987:283643-284002 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References