Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 69761..70362 Replicon plasmid pE6474.2
Accession NZ_CP116983
Organism Escherichia coli strain E6474

Toxin (Protein)


Gene name doc Uniprot ID F4TND7
Locus tag PO910_RS24275 Protein ID WP_001216030.1
Coordinates 69761..70141 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag PO910_RS24280 Protein ID WP_001190712.1
Coordinates 70141..70362 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO910_RS24245 (PO910_24245) 64861..64980 - 120 WP_001376634.1 ash family protein -
PO910_RS24250 (PO910_24250) 65202..66686 - 1485 WP_000124159.1 hypothetical protein -
PO910_RS24255 (PO910_24255) 66686..67879 - 1194 WP_094320460.1 terminase -
PO910_RS24260 (PO910_24260) 67965..68417 - 453 WP_001326849.1 late promoter-activating protein -
PO910_RS24265 (PO910_24265) 68506..69549 - 1044 WP_069187067.1 DUF968 domain-containing protein -
PO910_RS24270 (PO910_24270) 69577..69756 - 180 WP_001339207.1 hypothetical protein -
PO910_RS24275 (PO910_24275) 69761..70141 - 381 WP_001216030.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PO910_RS24280 (PO910_24280) 70141..70362 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PO910_RS24285 (PO910_24285) 70545..72101 + 1557 WP_063856231.1 type I restriction-modification system subunit M -
PO910_RS24290 (PO910_24290) 72098..73381 + 1284 WP_001617890.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..98542 98542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13601.29 Da        Isoelectric Point: 5.1408

>T269644 WP_001216030.1 NZ_CP116983:c70141-69761 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEDITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT269644 WP_001190712.1 NZ_CP116983:c70362-70141 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M1W8Q3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References