Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4230270..4230901 Replicon chromosome
Accession NZ_CP116981
Organism Escherichia coli strain E6474

Toxin (Protein)


Gene name hicA Uniprot ID F4NNK6
Locus tag PO910_RS20575 Protein ID WP_001259388.1
Coordinates 4230626..4230901 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag PO910_RS20570 Protein ID WP_000593555.1
Coordinates 4230270..4230629 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO910_RS20545 (4226402) 4226402..4227346 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
PO910_RS20550 (4227343) 4227343..4228176 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
PO910_RS20555 (4228176) 4228176..4228940 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
PO910_RS20560 (4228937) 4228937..4229743 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
PO910_RS20565 (4229749) 4229749..4230150 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
PO910_RS20570 (4230270) 4230270..4230629 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PO910_RS20575 (4230626) 4230626..4230901 - 276 WP_001259388.1 type II toxin-antitoxin system HicA family toxin Toxin
PO910_RS20580 (4230974) 4230974..4232098 - 1125 WP_001314210.1 ABC transporter permease -
PO910_RS20585 (4232098) 4232098..4234833 - 2736 WP_000149125.1 ribosome-associated ATPase/putative transporter RbbA -
PO910_RS20590 (4234830) 4234830..4235897 - 1068 WP_000361485.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10151.89 Da        Isoelectric Point: 10.7076

>T269636 WP_001259388.1 NZ_CP116981:c4230901-4230626 [Escherichia coli]
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT269636 WP_000593555.1 NZ_CP116981:c4230629-4230270 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A0FFA2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References