Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3228706..3229331 Replicon chromosome
Accession NZ_CP116981
Organism Escherichia coli strain E6474

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PO910_RS15645 Protein ID WP_000911330.1
Coordinates 3228706..3229104 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PO910_RS15650 Protein ID WP_000450524.1
Coordinates 3229104..3229331 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO910_RS15625 (3224613) 3224613..3224813 + 201 WP_124053586.1 YpfN family protein -
PO910_RS15630 (3224894) 3224894..3225592 - 699 WP_000679812.1 esterase -
PO910_RS15635 (3225666) 3225666..3227681 - 2016 WP_000829292.1 tRNA cytosine(34) acetyltransferase TmcA -
PO910_RS15640 (3227696) 3227696..3228559 - 864 WP_001267498.1 neutral zinc metallopeptidase -
PO910_RS15645 (3228706) 3228706..3229104 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
PO910_RS15650 (3229104) 3229104..3229331 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PO910_RS15655 (3229485) 3229485..3230198 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PO910_RS15660 (3230411) 3230411..3231445 - 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
PO910_RS15665 (3231462) 3231462..3232340 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
PO910_RS15670 (3232486) 3232486..3233058 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PO910_RS15675 (3233058) 3233058..3233528 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T269632 WP_000911330.1 NZ_CP116981:c3229104-3228706 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT269632 WP_000450524.1 NZ_CP116981:c3229331-3229104 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References