Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2117656..2118294 Replicon chromosome
Accession NZ_CP116981
Organism Escherichia coli strain E6474

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag PO910_RS10315 Protein ID WP_000813794.1
Coordinates 2117656..2117832 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PO910_RS10320 Protein ID WP_001270286.1
Coordinates 2117878..2118294 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO910_RS10295 (2113275) 2113275..2114450 - 1176 WP_001236215.1 BenE family transporter YdcO -
PO910_RS10300 (2114542) 2114542..2115078 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
PO910_RS10305 (2115151) 2115151..2117112 + 1962 WP_001593323.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PO910_RS10310 (2117204) 2117204..2117434 - 231 WP_000494244.1 YncJ family protein -
PO910_RS10315 (2117656) 2117656..2117832 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PO910_RS10320 (2117878) 2117878..2118294 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PO910_RS10325 (2118373) 2118373..2119778 + 1406 Protein_2013 PLP-dependent aminotransferase family protein -
PO910_RS10330 (2120023) 2120023..2121168 + 1146 WP_000047456.1 ABC transporter substrate-binding protein -
PO910_RS10335 (2121186) 2121186..2122199 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
PO910_RS10340 (2122200) 2122200..2123141 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T269625 WP_000813794.1 NZ_CP116981:2117656-2117832 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT269625 WP_001270286.1 NZ_CP116981:2117878-2118294 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References