Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1086717..1087335 Replicon chromosome
Accession NZ_CP116981
Organism Escherichia coli strain E6474

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PO910_RS05235 Protein ID WP_001291435.1
Coordinates 1086717..1086935 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PO910_RS05240 Protein ID WP_000344800.1
Coordinates 1086961..1087335 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO910_RS05200 (1082008) 1082008..1082580 + 573 WP_000779826.1 YbaY family lipoprotein -
PO910_RS05205 (1082611) 1082611..1082922 - 312 WP_000409911.1 MGMT family protein -
PO910_RS05215 (1083301) 1083301..1083654 + 354 WP_000878141.1 DUF1428 family protein -
PO910_RS05220 (1083696) 1083696..1085245 - 1550 Protein_1014 cyclic-guanylate-specific phosphodiesterase PdeB -
PO910_RS05225 (1085409) 1085409..1085879 - 471 WP_000136192.1 YlaC family protein -
PO910_RS05230 (1085995) 1085995..1086546 - 552 WP_000102564.1 maltose O-acetyltransferase -
PO910_RS05235 (1086717) 1086717..1086935 - 219 WP_001291435.1 HHA domain-containing protein Toxin
PO910_RS05240 (1086961) 1086961..1087335 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PO910_RS05245 (1087881) 1087881..1091030 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PO910_RS05250 (1091053) 1091053..1092246 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269617 WP_001291435.1 NZ_CP116981:c1086935-1086717 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269617 WP_000344800.1 NZ_CP116981:c1087335-1086961 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References