Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 381677..382272 Replicon chromosome
Accession NZ_CP116981
Organism Escherichia coli strain E6474

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag PO910_RS01825 Protein ID WP_000239579.1
Coordinates 381922..382272 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag PO910_RS01820 Protein ID WP_001223208.1
Coordinates 381677..381928 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO910_RS01810 (377342) 377342..381121 + 3780 WP_000060895.1 autotransporter assembly complex protein TamB -
PO910_RS01815 (381124) 381124..381465 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
PO910_RS01820 (381677) 381677..381928 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
PO910_RS01825 (381922) 381922..382272 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
PO910_RS01830 (382352) 382352..382882 - 531 WP_000055072.1 inorganic diphosphatase -
PO910_RS01835 (383192) 383192..384148 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
PO910_RS01840 (384458) 384458..385960 + 1503 WP_000205794.1 sugar ABC transporter ATP-binding protein -
PO910_RS01845 (385971) 385971..386995 + 1025 Protein_352 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T269614 WP_000239579.1 NZ_CP116981:381922-382272 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT269614 WP_001223208.1 NZ_CP116981:381677-381928 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References