Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 276840..277337 Replicon chromosome
Accession NZ_CP116981
Organism Escherichia coli strain E6474

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PO910_RS01285 Protein ID WP_001173343.1
Coordinates 277164..277337 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag PO910_RS01280 Protein ID WP_000398619.1
Coordinates 276840..277136 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO910_RS01260 (273571) 273571..274290 - 720 WP_000611288.1 two-component system response regulator DcuR -
PO910_RS01265 (274287) 274287..275918 - 1632 WP_001216487.1 sensor histidine kinase -
PO910_RS01270 (276099) 276099..276329 + 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
PO910_RS01275 (276341) 276341..276613 + 273 WP_000405649.1 GNAT family N-acetyltransferase -
PO910_RS01280 (276840) 276840..277136 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PO910_RS01285 (277164) 277164..277337 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PO910_RS01290 (277456) 277456..278973 - 1518 WP_001295074.1 lysine--tRNA ligase -
PO910_RS01295 (279210) 279210..280667 - 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T269613 WP_001173343.1 NZ_CP116981:277164-277337 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT269613 WP_000398619.1 NZ_CP116981:276840-277136 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References