Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4684..5219 Replicon plasmid pCUVM53-2
Accession NZ_CP116978
Organism Escherichia coli strain CUVM53

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PQP10_RS23385 Protein ID WP_032206513.1
Coordinates 4684..4971 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag PQP10_RS23390 Protein ID WP_001139206.1
Coordinates 4968..5219 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP10_RS23370 (PQP10_23370) 309..3824 + 3516 WP_072752622.1 autotransporter outer membrane beta-barrel domain-containing protein -
PQP10_RS23375 (PQP10_23375) 3999..4204 - 206 Protein_2 hypothetical protein -
PQP10_RS23380 (PQP10_23380) 4203..4316 + 114 Protein_3 alkaline phosphatase -
PQP10_RS23385 (PQP10_23385) 4684..4971 - 288 WP_032206513.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP10_RS23390 (PQP10_23390) 4968..5219 - 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQP10_RS23395 (PQP10_23395) 5879..9769 + 3891 WP_250191322.1 helicase-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid tet(A) / blaTEM-176 / qnrS1 / aph(3'')-Ib / aph(6)-Id - 1..98110 98110


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11130.20 Da        Isoelectric Point: 10.5833

>T269610 WP_032206513.1 NZ_CP116978:c4971-4684 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQIIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT269610 WP_001139206.1 NZ_CP116978:c5219-4968 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References