Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 992189..992808 Replicon chromosome
Accession NC_017540
Organism Klebsiella pneumoniae KCTC 2242

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KPN2242_RS04875 Protein ID WP_002892050.1
Coordinates 992189..992407 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KPN2242_RS04880 Protein ID WP_002892066.1
Coordinates 992434..992808 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPN2242_RS04840 988236..988499 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
KPN2242_RS04845 988499..988639 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KPN2242_RS04850 988636..989334 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
KPN2242_RS04855 989435..990886 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KPN2242_RS04860 990861..991331 - 471 WP_002892026.1 YlaC family protein -
KPN2242_RS29485 991352..991492 + 141 WP_004147370.1 hypothetical protein -
KPN2242_RS04870 991464..992030 - 567 WP_002892030.1 maltose O-acetyltransferase -
KPN2242_RS04875 992189..992407 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
KPN2242_RS04880 992434..992808 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KPN2242_RS04885 993294..996440 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KPN2242_RS04890 996463..997656 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T26961 WP_002892050.1 NC_017540:c992407-992189 [Klebsiella pneumoniae KCTC 2242]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T26961 NC_017540:c992407-992189 [Klebsiella pneumoniae KCTC 2242]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT26961 WP_002892066.1 NC_017540:c992808-992434 [Klebsiella pneumoniae KCTC 2242]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT26961 NC_017540:c992808-992434 [Klebsiella pneumoniae KCTC 2242]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References