Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1981..2540 Replicon plasmid pCUVM53-1
Accession NZ_CP116977
Organism Escherichia coli strain CUVM53

Toxin (Protein)


Gene name relE Uniprot ID U9YB49
Locus tag PQP10_RS22790 Protein ID WP_000421259.1
Coordinates 2265..2540 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y625
Locus tag PQP10_RS22785 Protein ID WP_001178087.1
Coordinates 1981..2265 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP10_RS22780 (46) 46..1077 + 1032 WP_052980407.1 plasmid replication initiator RepA -
PQP10_RS22785 (1981) 1981..2265 + 285 WP_001178087.1 ribbon-helix-helix domain-containing protein Antitoxin
PQP10_RS22790 (2265) 2265..2540 + 276 WP_000421259.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP10_RS22795 (2646) 2646..2849 + 204 Protein_3 hypothetical protein -
PQP10_RS22800 (3501) 3501..4205 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
PQP10_RS22805 (4343) 4343..4723 - 381 WP_039026395.1 diacylglycerol kinase -
PQP10_RS22810 (4841) 4841..6466 - 1626 WP_089613755.1 phosphoethanolamine--lipid A transferase MCR-3.5 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mcr-3.5 - 1..100405 100405


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.45 Da        Isoelectric Point: 9.9324

>T269605 WP_000421259.1 NZ_CP116977:2265-2540 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10488.92 Da        Isoelectric Point: 5.6558

>AT269605 WP_001178087.1 NZ_CP116977:1981-2265 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YB49

Antitoxin

Source ID Structure
AlphaFold DB U9Y625

References