Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 4569378..4570083 Replicon chromosome
Accession NZ_CP116976
Organism Escherichia coli strain CUVM53

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag PQP10_RS22145 Protein ID WP_000539521.1
Coordinates 4569697..4570083 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PQP10_RS22140 Protein ID WP_001280945.1
Coordinates 4569378..4569707 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP10_RS22125 (4564535) 4564535..4565446 + 912 WP_001236042.1 glutathione ABC transporter permease GsiD -
PQP10_RS22130 (4565624) 4565624..4567972 + 2349 WP_001338403.1 EAL domain-containing protein -
PQP10_RS22135 (4567980) 4567980..4569308 + 1329 WP_000086877.1 GGDEF domain-containing protein -
PQP10_RS22140 (4569378) 4569378..4569707 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
PQP10_RS22145 (4569697) 4569697..4570083 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP10_RS22150 (4570309) 4570309..4571634 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
PQP10_RS22155 (4571847) 4571847..4572230 + 384 WP_000497137.1 biofilm formation regulator BssR -
PQP10_RS22160 (4572341) 4572341..4573456 + 1116 WP_000555031.1 aldose sugar dehydrogenase YliI -
PQP10_RS22165 (4573453) 4573453..4574079 - 627 WP_094337114.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T269604 WP_000539521.1 NZ_CP116976:c4570083-4569697 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT269604 WP_001280945.1 NZ_CP116976:c4569707-4569378 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References