Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4183002..4183620 Replicon chromosome
Accession NZ_CP116976
Organism Escherichia coli strain CUVM53

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PQP10_RS20240 Protein ID WP_001291435.1
Coordinates 4183002..4183220 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PQP10_RS20245 Protein ID WP_000344800.1
Coordinates 4183246..4183620 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP10_RS20205 (4178291) 4178291..4178863 + 573 WP_000779831.1 YbaY family lipoprotein -
PQP10_RS20210 (4178894) 4178894..4179205 - 312 WP_000409911.1 MGMT family protein -
PQP10_RS20220 (4179584) 4179584..4179937 + 354 WP_000878140.1 DUF1428 domain-containing protein -
PQP10_RS20225 (4179979) 4179979..4181529 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PQP10_RS20230 (4181693) 4181693..4182163 - 471 WP_000136192.1 YlaC family protein -
PQP10_RS20235 (4182279) 4182279..4182830 - 552 WP_000102564.1 maltose O-acetyltransferase -
PQP10_RS20240 (4183002) 4183002..4183220 - 219 WP_001291435.1 HHA domain-containing protein Toxin
PQP10_RS20245 (4183246) 4183246..4183620 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PQP10_RS20250 (4184166) 4184166..4187315 - 3150 WP_089674075.1 efflux RND transporter permease AcrB -
PQP10_RS20255 (4187338) 4187338..4188531 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269603 WP_001291435.1 NZ_CP116976:c4183220-4183002 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269603 WP_000344800.1 NZ_CP116976:c4183620-4183246 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References