Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3919184..3919838 Replicon chromosome
Accession NZ_CP116976
Organism Escherichia coli strain CUVM53

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag PQP10_RS19000 Protein ID WP_000244777.1
Coordinates 3919431..3919838 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PQP10_RS18995 Protein ID WP_000354046.1
Coordinates 3919184..3919450 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP10_RS18970 (3914353) 3914353..3915096 + 744 WP_000951948.1 SDR family oxidoreductase -
PQP10_RS18975 (3915153) 3915153..3916586 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
PQP10_RS18980 (3916631) 3916631..3916942 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
PQP10_RS18985 (3917106) 3917106..3917765 + 660 WP_000250274.1 hemolysin III family protein -
PQP10_RS18990 (3917961) 3917961..3918941 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
PQP10_RS18995 (3919184) 3919184..3919450 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PQP10_RS19000 (3919431) 3919431..3919838 + 408 WP_000244777.1 protein YgfX Toxin
PQP10_RS19005 (3919878) 3919878..3920399 - 522 WP_001055874.1 flavodoxin FldB -
PQP10_RS19010 (3920511) 3920511..3921407 + 897 WP_000806639.1 site-specific tyrosine recombinase XerD -
PQP10_RS19015 (3921432) 3921432..3922142 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQP10_RS19020 (3922148) 3922148..3923881 + 1734 WP_272771711.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T269600 WP_000244777.1 NZ_CP116976:3919431-3919838 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT269600 WP_000354046.1 NZ_CP116976:3919184-3919450 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References