Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 582256..582894 Replicon chromosome
Accession NZ_CP116976
Organism Escherichia coli strain CUVM53

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag PQP10_RS02890 Protein ID WP_000813794.1
Coordinates 582256..582432 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PQP10_RS02895 Protein ID WP_001270286.1
Coordinates 582478..582894 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP10_RS02870 (577875) 577875..579050 - 1176 WP_272772226.1 BenE family transporter YdcO -
PQP10_RS02875 (579142) 579142..579678 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
PQP10_RS02880 (579751) 579751..581712 + 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PQP10_RS02885 (581804) 581804..582034 - 231 WP_000494244.1 YncJ family protein -
PQP10_RS02890 (582256) 582256..582432 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PQP10_RS02895 (582478) 582478..582894 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PQP10_RS02900 (582973) 582973..584379 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
PQP10_RS02905 (584624) 584624..585769 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
PQP10_RS02910 (585787) 585787..586800 + 1014 WP_000220399.1 ABC transporter ATP-binding protein -
PQP10_RS02915 (586801) 586801..587742 + 942 WP_001251313.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T269588 WP_000813794.1 NZ_CP116976:582256-582432 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT269588 WP_001270286.1 NZ_CP116976:582478-582894 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References